Juq-275 -

Key pharmacodynamic features reported in the literature include:

| Feature | Observation | |---------|--------------| | | 28 nM (enzyme assay) | | Selectivity | > 150‑fold selectivity over the closely related MNK2 and a panel of 45 kinases | | Cellular potency | Decrease of p‑eIF4E (Ser209) with EC₅₀ ≈ 120 nM in HCT‑116 colorectal cancer cells | | Down‑stream effects | Reduced levels of cyclin D1, Bcl‑2, and VEGF; G1‑phase cell‑cycle arrest | JUQ-275

If forthcoming studies confirm its safety and efficacy, JUQ‑275 could become a valuable addition to the armamentarium against hard‑to‑treat cancers and inflammatory diseases, offering a novel means of “dialing down” pathological protein synthesis without the broad toxicity associated with upstream kinase inhibitors. Prepared for academic and research‑strategy purposes; all data reflect the publicly available literature up to April 2026. JUQ-275