The pharmaceutical industry has also contributed to the problem. Developing new antibiotics is expensive and, paradoxically, not very profitable. Since antibiotics are used for short durations and must be reserved to prevent resistance, companies struggle to recoup research costs. Consequently, the antibiotic pipeline has dried up. While 40 new antibiotics were approved between 1980 and 2000, only 12 have been approved since 2010. The World Health Organization (WHO) has identified a ‘priority pathogen list’ of bacteria—including carbapenem-resistant Acinetobacter and drug-resistant tuberculosis—for which no effective drugs remain in development.
Antibiotic resistance develops when bacteria adapt to survive drugs. Human activities have (6) ______ this natural process. In farming, antibiotics are used for growth and (7) ______, leading to resistant bacteria entering water systems. As a result, routine operations like hip replacements may become (8) ______. To solve this, experts propose a (9) ______ approach combining human, animal, and environmental strategies. The pharmaceutical industry has also contributed to the
The consequences are already measurable. According to a 2022 report in The Lancet , approximately 1.27 million deaths were directly attributed to antibiotic-resistant infections in 2019, with nearly 5 million associated deaths. Without intervention, the Organisation for Economic Co-operation and Development (OECD) projects that by 2050, resistance could cause 10 million deaths annually—exceeding cancer’s toll. Routine medical procedures, such as hip replacements or caesarean sections, would become high-risk due to untreatable post-operative infections. Consequently, the antibiotic pipeline has dried up